ea0004p50 | Endocrine tumours and neoplasia | SFE2002
Bibi R
, Diaz-Cano S
, Vax V
, Gueorguiev M
, Kola B
, Bressac B
, Walker G
, Grossman A
, Korbonits M
BACKGROUND: Cell cycle dysregulation is one of the defining features of cancer. Cyclin-dependent kinase 4 (CDK4), together with its regulatory subunit Cyclin D, governs cell cycle progression in G1 phase. CDK4 is in turn regulated by cyclin-dependent kinase inhibitors, including p16INK4A (CDKN2A). Dysregulation of the INK4A/CDK4/cyclin D complex has been established in different a variety of types of human tumours. Dominant mutations affecting codon 24 of the CDK4 gene (replac...